Ninatoka

Glucose transporters

concept

GLUT4

GLUT4 functions for the insulin-dependent translocation of glucose. Thus, insulin stimulates the uptake of glucose by GLUT4 in the muscle cell where hexokinase converts it to glucose-6-phosphate so that the cell may utilize it for either glycolysis for energy or for the formation of glycogen when glucose is abundant. In the adipocyte, GLUT4 also responds to insulin for the uptake of glucose where it is again converted to glucose-6-phosphate by hexokinase and then converted to glycerol-3-phosphate for conversion to trigylcerides. Also under the control of insulin, lipoproteins in the plasma form fatty acids within the cell under the action of lipoprotein lipase and these fatty acids also are used for triglyceride synthesis. In addition, insulin inhibits the breakdown of triglycerides to fatty acids in these cells.

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Added on Apr 7, 2022 by Barbara Van De Keer
Edited on Jan 7, 2023 by Barbara Van De Keer