concept

Inhibin

Inhibin, a heterodimeric glycoprotein product of the Sertoli cell of the testes and the ovarian granulosa cell (as well as the placenta and other tissues), exerts negative feedback action on the secretion of FSH from the pituitary. Inhibin is composed of an α-subunit and one of two β-subunits, βA or βB, which, respectively, form inhibin A or inhibin B, dimers with apparently identical function. Inhibin is a member of the transforming growth factor-β (TGFβ) superfamily that includes antimüllerian hormone (AMH) and the dimers of two inhibin subunits, activin A and activin B, which stimulate the release of FSH from pituitary cells.270 Synthesis and secretion of gonadal inhibin are induced by FSH. Inhibin plays a role in the feedback regulation of FSH secretion during puberty in males and females.

Ref:
Physiology and Disorders of Puberty Dennis M. Styne Williams Textbook of Endocrinology, 26, 1023-1164

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Added on Sep 9, 2022 by Barbara Van De Keer
Edited on Sep 9, 2022 by Barbara Van De Keer

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