concept

Globeth cell

Goblet cells are interspersed among the enterocytes. They are polarized, mucous-secreting cells, increasing in number distally. They are easily recognizable by their pear-shaped region containing the mass of mature mucigen granules. Often a small “puff” of mucous can be distinguished emerging from the apex. Apical microvilli are sparse and irregular in size and shape. Cytoplasmic organelles, including a well developed network of rough endoplasmic reticulum, free ribosomes, mitochondria, and lysosomes, lie around the mass of mucous granules. Last, intraepithelial lymphocytes, mainly T cells, lie between individual epithelial cells, usually just above the basement membrane. The ratio of epithelial cells to intraepithelial lymphocytes is about 6 : 1.

Ref:
Gaëlle Boudry, Ping-Chang Yang, Mary H. Perdue, Small Intestine, Anatomy, Editor(s): Leonard R. Johnson, Encyclopedia of Gastroenterology, Elsevier, 2004, Pages 404-409, ISBN 9780123868602, https://doi.org/10.1016/B0-12-386860-2/00648-1. (https://www.sciencedirect.com/science/article/pii/B0123868602006481)

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Added on Sep 24, 2022 by Barbara Van De Keer

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