condition

Cortisol resistance

Published April 2nd, 2012 in the Proceedings of the National Academy of Sciences (PNAS), the research was separated into 2 viral-challenge studies. The first study was meant to determine whether stress causes cortisol resistance and whether people with cortisol resistance are more likely to develop a common cold. Two hundred and seventy-six healthy volunteers were assessed for recent stressful life events, glucocorticoid receptor resistance (GCR), and various baseline levels such as race, sex, age, BMI. The volunteers were quarantined, exposed to a virus, and followed for 5 days. Those volunteers with a recent exposure to a long-term stressful event demonstrated glucocorticoid receptor resistance (GCR), and those with GCR were at higher risk of subsequently developing a cold. The second study was meant to determine whether cortisol resistance could make a person have more inflammation. Using the same control variables, 79 volunteers were exposed to a virus and monitored at baseline and for 5 d ays after the viral challenge for the production of local inflammatory markers in their nasal secretions. It was found that people with greater glucocorticoid receptor resistance had more local proinflammatory cytokines among infected subjects.

Ref:
Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk Sheldon Cohen scohen@cmu.edu, Denise Janicki-Deverts, William J. Doyle, +3 , Gregory E. Miller, Ellen Frank, Bruce S. Rabin, and Ronald B. Turner-3Authors Info & Affiliations Edited* by Bruce S. McEwen, The Rockefeller University, New York, NY, and approved February 27, 2012 (received for review November 7, 2011) April 2, 2012 109 (16) 5995-5999 https://doi.org/10.1073/pnas.1118355109

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Added on May 16, 2022 by Barbara Van De Keer
Edited on Jul 12, 2022 by Barbara Van De Keer

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