concept

Pancreatic secretory trypsin inhibitor (PSTI)

Trypsin activity is properly suppressed in the pancreatic acinar cells under normal conditions. A small amount of trypsinogen is converted to active trypsin and inactivated by pancreatic secretory trypsin inhibitor (PSTI), thereby preventing damage to pancreatic acinar cells as a first line of defense.

Ref:
Hirota M, Ohmuraya M, Baba H. The role of trypsin, trypsin inhibitor, and trypsin receptor in the onset and aggravation of pancreatitis. J Gastroenterol. 2006 Sep;41(9):832-6. doi: 10.1007/s00535-006-1874-2. PMID: 17048046.

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Added on Sep 25, 2022 by Barbara Van De Keer

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