process

Activation of digestive enzymes

The major physiological actions of secretin are stimulation of pancreatic fluid and bicarbonate secretion. S cells in the small intestine emit secretin. Gastric acid stimulates secretin release, allowing movement into the duodenal lumen. Secretin causes an increase in pancreatic and biliary bicarbonate secretion and a decrease in gastric H+ secretion. Secretin stimulates the secretion of bicarbonate-rich pancreatic fluid.[11] Secretin enters the intestinal lumen and stimulates bicarbonate secretion, ultimately neutralizing gastric H+, which plays an essential role in fat digestion by creating a more neutral (pH 6 to 8) environment. H+ and fatty acids in the duodenum regulate secretin release. Secretin neutralizes the pH in the duodenum by optimizing the functionality of pancreatic amylase and pancreatic lipase. (1) Via the second messenger action of cAMP, bicarbonate release causes neutralization of the acidic environment, thus establishing a pH favorable for the action of digestive enzymes.[12] Secretin increases bicarbonate secretion from duodenal Brunner's gland as well; this mechanism buffers the acidity from chyme and reduces secretion of acid by parietal cells.

Ref:
DiGregorio N, Sharma S. Physiology, Secretin. [Updated 2022 May 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537116/

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Added on Sep 25, 2022 by Barbara Van De Keer
Edited on Sep 28, 2022 by Barbara Van De Keer

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