concept

Angiotensin 2

Angiotensin II is the most biologically active effector peptide of the RAS and binds to either the angiotensin II type 1 (Agtr1) receptor located within the renal tubule to increase sodium reabsorption or the Agtr2 receptor to decrease sodium reabsorption. While in species such as the human and sheep, a single Agtr1 isoform exists, in the rodent, two genes collectively perform these functions, namely Agtr1a and Agtr1b. In addition to the direct role of Agtr1 and Agtr2 in the kidney itself, signaling through these receptors in other tissues can indirectly influence renal function via adrenal production of aldosterone or through vascular effects. In addition to this predominant arm of the RAS, a number of additional peptides, enzymes, and receptors have all been shown to play a role in renal function and adult disease. Interestingly, in many organs, including the kidney, all components of the RAS are thought to coexist suggesting a role for a complete local RAS in such tissues. Programmed alterations to this system can have profound effects on both renal function and cardiovascular outcomes.

Ref:
James S.M. Cuffe, Sarah L. Walton, Karen M. Moritz, Chapter 15 - The Developmental Origins of Renal Dysfunction, Editor(s): Cheryl S. Rosenfeld, The Epigenome and Developmental Origins of Health and Disease, Academic Press, 2016, Pages 291-314, ISBN 9780128013830, https://doi.org/10.1016/B978-0-12-801383-0.00015-3. (https://www.sciencedirect.com/science/article/pii/B9780128013830000153)

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Added on Sep 26, 2022 by Barbara Van De Keer
Edited on Sep 26, 2022 by Barbara Van De Keer

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