concept

Hyaluronic acid

Hyaluronic acid (HA) has the simplest structure of all GAGs and does not require additional sulfation of functional groups in the Golgi apparatus as do the other GAGs. Instead, the structure consists of sequentially bound glucuronic acid and N-acetylglucosamine residues.[4] These monosaccharide building blocks are synthesized in the cell cytoplasm and are recruited to the plasma membrane by diffusion for HA synthesis.[3] After synthesis within the plasma membrane, HA gets secreted from the cell into the extracellular space unmodified.

Ref:
Casale J, Crane JS. Biochemistry, Glycosaminoglycans. [Updated 2022 Mar 27]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK544295/

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Added on Sep 27, 2022 by Barbara Van De Keer
Edited on Sep 27, 2022 by Barbara Van De Keer

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