concept

Glucosamine

Glucosamine is an endogenous aminomonosaccharide synthesized from glucose naturally in the body.61 It is used in the biosynthesis of proteoglycans and glycosaminoglycans, which are the building blocks of cartilage.61 The lack of proteoglycans can lead to degeneration of articular cartilage.62 In vitro and animal studies showed that glucosamine affects the cytokine-mediated pathways regulating inflammation, cartilage degradation, and immune responses.63,64 The most common forms of glucosamine are glucosamine sulfate and glucosamine hydrochloride. The glucosamine supplements are usually made from animal sources such as crab, lobster, or shrimp shells. Glucosamine is the supplement most commonly used by patients with OA.

Ref:
Yuan Z. Lim, Sultana Monira Hussain, Flavia M. Cicuttini, Yuanyuan Wang, Chapter 6 - Nutrients and Dietary Supplements for Osteoarthritis, Editor(s): Ronald Ross Watson, Victor R. Preedy, Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases (Second Edition), Academic Press, 2019, Pages 97-137, ISBN 9780128138205, https://doi.org/10.1016/B978-0-12-813820-5.00006-4. (https://www.sciencedirect.com/science/article/pii/B9780128138205000064)

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Added on Sep 27, 2022 by Barbara Van De Keer

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