process

Acetyl-CoA synthesis from pyruvate oxidation

Pyruvate decarboxylase (PDC) catalyzes the decarboxylation of pyruvate anion by a factor of around 10(12), compared with the non-enzymic decarboxylation by thiamine, under standard state conditions of 1 mM pyruvate and thiamine diphosphate (TDP), pH 6.2.

Ref:
Huhta DW, Heckenthaler T, Alvarez FJ, Ermer J, Hübner G, Schellenberger A, Schowen RL. The catalytic power of pyruvate decarboxylase. A stochastic model for the molecular evolution of enzymes. Acta Chem Scand (Cph). 1992 Aug;46(8):778-88. doi: 10.3891/acta.chem.scand.46-0778. PMID: 1497997.

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Added on Oct 1, 2022 by Barbara Van De Keer
Edited on Jan 8, 2023 by Barbara Van De Keer

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