enzyme

Fructokinase isoform C

Fructokinase occurs in two different isoforms, isoform A and isoform C. In addition to having a ubiquitous tissue distribution, Isoform A has a lower affinity for fructose, which seems to diminish the amount of fructose available for metabolism by the liver. However, Isoform C is mainly present in the liver, intestine, and kidney and has a high affinity for fructose, leading to the rapid incorporation of fructose for metabolism.

Ref:
Dholariya SJ, Orrick JA. Biochemistry, Fructose Metabolism. [Updated 2021 Oct 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK576428/

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Added on Oct 2, 2022 by Barbara Van De Keer

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