enzyme

Aldose reductase

In the polyol pathway, glucose converts into sorbitol by aldolase reductase. Sorbitol further oxidizes into fructose by sorbitol dehydrogenase, which accounts for the appearance of fructose in seminal plasma. A seminal vesicle, hepatocytes, and ovarian cells express aldose reductase and sorbitol dehydrogenase, which synthesize fructose from the glucose. ---------------------- Aldolase reductase is an enzyme that is part of the alpha-keto reductase superfamily that uses NADPH to drive the forward reaction.[9] Aldolase reductase has the ability to reduce a wide variety of aldehydes due to its broad specificity, as first studied by H.G. Hers in 1960.[10] Aldolase reductase is an enzyme that has a relatively low affinity for glucose (high Km). This means that under normal glucose levels, the low affinity of aldolase reductase to glucose reduces the activity of the enzyme and the pathway overall.

Ref:
Dholariya SJ, Orrick JA. Biochemistry, Fructose Metabolism. [Updated 2021 Oct 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK576428/ ------------- Srikanth KK, Orrick JA. Biochemistry, Polyol Or Sorbitol Pathways. [Updated 2022 Nov 14]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK576381/

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Added on Oct 2, 2022 by Barbara Van De Keer
Edited on Sep 14, 2023 by Barbara Van De Keer

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