enzyme

Glutathione transferases

Glutathione transferases (EC 2.5.1.18) catalyze glutathione conjugation to electrophilic compounds, primarily produced from exogenous xenobiotics by biotransformation but which can also arise from endogenous substances. The glutathione conjugation reaction is the first step of the mercapturic acid pathway, which is one of the most important detoxication processes (Fig. 1). The second step is catalyzed by γ-glutamyltransferase. In addition to this conjugation reaction, some forms of the enzyme exhibit isomerase activity toward ketosteroids and glutathione peroxidase activity toward lipid and nucleic acid hydroperoxides and also act as binding (carrier) proteins.

Ref:
Shigeki Tsuchida, Glutathione Transferases, Editor(s): Joseph R. Bertino, Encyclopedia of Cancer (Second Edition), Academic Press, 2002, Pages 297-307, ISBN 9780122275555, https://doi.org/10.1016/B0-12-227555-1/00513-X. (https://www.sciencedirect.com/science/article/pii/B012227555100513X)

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Added on Oct 2, 2022 by Barbara Van De Keer

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