condition

Liver fibrosis (hepatic fibrosis)

Liver fibrosis is the excessive accumulation of extracellular matrix proteins including collagen that occurs in most types of chronic liver diseases. Advanced liver fibrosis results in cirrhosis, liver failure, and portal hypertension and often requires liver transplantation. Our knowledge of the cellular and molecular mechanisms of liver fibrosis has greatly advanced. Activated hepatic stellate cells, portal fibroblasts, and myofibroblasts of bone marrow origin have been identified as major collagen-producing cells in the injured liver. These cells are activated by fibrogenic cytokines such as TGF-β1, angiotensin II, and leptin.

Ref:
Published in Volume 115, Issue 2 on February 1, 2005 J Clin Invest. 2005;115(2):209–218. https://doi.org/10.1172/JCI24282. © 2005 The American Society for Clinical Investigation

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Added on Oct 2, 2022 by Barbara Van De Keer
Edited on Nov 5, 2023 by Barbara Van De Keer

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