concept

Glutathione (GSH)

Glutathione, also referred to as GSH, is an endogenous component of cellular metabolism, a tripeptide composed of glycine, cysteine, and glutamic acid. It is normally present in the liver at a concentration of 10 mmol l−1. It is an integral part of the biotransformation of xenobiotic substances, and serves to protect the body from reducing agents. Glutathione conjugation (facilitated by a family of glutathione transferase enzymes) helps contribute to detoxification by binding electrophiles that could otherwise bind to proteins or nucleic acids, resulting in cellular damage and genetic mutations. It has been reported that binding sites provided with true specificity for GSH exist in the central nervous system, and this satisfies the main requisite for considering GSH as a neuromediator in addition to its other functions.

Ref:
S.C. Gad, Glutathione, Editor(s): Philip Wexler, Encyclopedia of Toxicology (Third Edition), Academic Press, 2014, Page 751, ISBN 9780123864550, https://doi.org/10.1016/B978-0-12-386454-3.00850-2. (https://www.sciencedirect.com/science/article/pii/B9780123864543008502)

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Added on May 15, 2022 by Barbara Van De Keer
Edited on Nov 9, 2022 by Barbara Van De Keer

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