concept

Ovarian follicle

The follicle is the functional unit of the ovary, which is composed of three types of cells: oocytes, granulosa cells, and theca cells. Ovarian follicle development and the subsequent ovulation process are coordinated by highly complex interplay between endocrine, paracrine, and autocrine signals, which coordinate steroidogenesis and gametogenesis. Follicle development is regulated mainly by three organs, the hypothalamus, anterior pituitary, and gonad, which make up the hypothalamic-pituitary-gonadal axis. Steroid hormones and their receptors play pivotal roles in follicle development and participate in a series of classical signaling pathways.

Ref:
Li L, Shi X, Shi Y and Wang Z (2021) The Signaling Pathways Involved in Ovarian Follicle Development. Front. Physiol. 12:730196. doi: 10.3389/fphys.2021.730196

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Added on Oct 8, 2022 by Barbara Van De Keer

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