process

Homocysteine to methionine conversion

In the methionine cycle, Fig. 41.2, homocysteine is converted to methionine, and the enzyme involved is betaine homocysteine methyltransferase (BHMT). This reaction is independent of the one that is mediated by MS and independent of vitamin B12 or the folate cycle. In this case, methionine is regenerated from homocysteine by the transfer of a methyl group from trimethylglycine (TMG) to homocysteine (Brouwer et al., 2000). Once TMG loses a methyl group to homocysteine, it converts to dimethylglycine (DMG). In turn, homocysteine gains a methyl group and becomes methionine.

Ref:
Amalia Tsiami, Derek Obersby, 41 - B Vitamins Intake and Plasma Homocysteine in Vegetarians, Editor(s): François Mariotti, Vegetarian and Plant-Based Diets in Health and Disease Prevention, Academic Press, 2017, Pages 747-767, ISBN 9780128039687, https://doi.org/10.1016/B978-0-12-803968-7.00041-1. (https://www.sciencedirect.com/science/article/pii/B9780128039687000411)

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Added on Oct 14, 2022 by Barbara Van De Keer
Edited on Oct 14, 2022 by Barbara Van De Keer

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