process

Beta oxidation

Fatty acid oxidation is the mitochondrial aerobic process of breaking down a fatty acid into acetyl-CoA units. Fatty acids move in this pathway as CoA derivatives utilizing NAD and FAD. Fatty acids are activated before oxidation, utilizing ATP in the presence of CoA-SH and acyl-CoA synthetase. Long-chain acyl-CoA enters mitochondria bound to carnitine. Inside mitochondria beta oxidation of fatty acids takes place in which two carbon atoms are removed in the form of acetyl-CoA from acyl-CoA at the carboxyl terminal. The bond is broken between the second carbon/beta carbon and the third carbon/gamma carbon, hence the name beta oxidation. This process provides energy from fats.

Ref:
Asha Kumari, Chapter 4 - Beta Oxidation of Fatty Acids, Editor(s): Asha Kumari, Sweet Biochemistry, Academic Press, 2018, Pages 17-19, ISBN 9780128144534, https://doi.org/10.1016/B978-0-12-814453-4.00004-2. (https://www.sciencedirect.com/science/article/pii/B9780128144534000042)

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Added on May 12, 2022 by Barbara Van De Keer
Edited on Aug 25, 2022 by Barbara Van De Keer

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