enzyme

Catecholamine-O-methyltransferase (COMT)

Catechol O-methyltransferase (COMT, EC 2.1.1.6) is important in the central nervous system because it metabolizes catecholamine neurotransmitters such as dopamine. The enzyme catalyses the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to one hydroxyl group of catechols.

Ref:
Vidgren J, Svensson LA, Liljas A. Crystal structure of catechol O-methyltransferase. Nature. 1994 Mar 24;368(6469):354-8. doi: 10.1038/368354a0. PMID: 8127373.

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Added on Oct 22, 2022 by Barbara Van De Keer
Edited on Jan 5, 2023 by Barbara Van De Keer

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