concept

PIBAT cell (Pro-inflammatory brain-autoreactive T-cells)

Under physiological conditions, the number, secretory profile and homing properties of pro-inflammatory brain-autoreactive T-cells (PIBAT cells) supports finely-tuned cognition-promoting autoimmunity. In particular, PIBAT cells exert at distance trophic effects on neurons via cytokines and neurotrophins that are appropriately synthesized (qualitatively and quantitatively). Cognition-promoting autoimmunity allows an overall harmonious co-development, co-maintenance and co-aging of the nervous and immune systems. It is proposed that alterations in the number, secretory profile and/or homing behavior of PIBAT cells are involved in the pathophysiology of CNS autoimmune disorders, non-CNS autoimmune disorders, psychiatric diseases and neurodegenerative conditions.

Ref:
Nataf, Serge. (2017). Autoimmunity as a Driving Force of Cognitive Evolution. Frontiers in Neuroscience. 11. 10.3389/fnins.2017.00582.

20 confidence points
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Added on Nov 13, 2022 by Barbara Van De Keer

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