concept

Nucleotide-binding domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) (NLRP3)

NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is a cytosolic pattern recognition receptor (PRR) that recognizes multiple pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Once activated, NLRP3 initiates the inflammasome assembly together with the adaptor ASC and the effector caspase-1, leading to caspase-1 activation and subsequent cleavage of IL-1β and IL-18. Aberrant NLRP3 inflammasome activation is linked with the pathogenesis of multiple inflammatory diseases, such as cryopyrin-associated periodic syndromes, type 2 diabetes, non-alcoholic steatohepatitis, gout, and neurodegenerative diseases.

Ref:
Zhan X, Li Q, Xu G, Xiao X, Bai Z. The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors. Front Immunol. 2023 Jan 18;13:1109938. doi: 10.3389/fimmu.2022.1109938. PMID: 36741414; PMCID: PMC9889537.

20 confidence points
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Added on Nov 17, 2022 by Barbara Van De Keer
Edited on Jun 25, 2023 by Barbara Van De Keer

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