enzyme

HIOMT (hydroxyindole-O-methyltransferase)

Pineal-derived melatonin is synthesized from tryptophan, which is first converted into 5-hydroxytrophan by tryptophan hydroxylase and then decarboxylated into serotonin (5-HT). Two additional steps transform 5-HT into melatonin, including the rate-limiting step catalyzed by the enzyme aralkylamineN-acetyltransferase (AANAT) to yieldN-acetylserotonin, followed by the transfer of a methyl group from S-adenosyl methionine to the 5-hydroxy group ofN-acetylserotonin by hydroxyindole-O-methyltransferase (HIOMT).

Ref:
Ronald M. Lechan Williams Textbook of Endocrinology, 7, 114-183.e17

20 confidence points
0 comments
Added on Nov 21, 2022 by Barbara Van De Keer
Edited on Oct 22, 2023 by Barbara Van De Keer

Join Ninatoka!!

NinatoKa's goal is to support you as a therapist in unravelling the illness pathway from symptoms to cause, and to help you detect potential interventions.

Go to Explore to start your discovery!

Go to Learn to scroll through newly added data.

Go to Contribute to contribute to the Ninatoka database.

You can rate content up or down and add comments if you agree or disagree.