process

Glucose to Sorbitol conversion

In the polyol pathway, glucose converts into sorbitol by aldolase reductase. Sorbitol further oxidizes into fructose by sorbitol dehydrogenase, which accounts for the appearance of fructose in seminal plasma. A seminal vesicle, hepatocytes, and ovarian cells express aldose reductase and sorbitol dehydrogenase, which synthesize fructose from the glucose.

Ref:
Dholariya SJ, Orrick JA. Biochemistry, Fructose Metabolism. [Updated 2021 Oct 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK576428/

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Added on Nov 22, 2022 by Barbara Van De Keer

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