enzyme

DPP-4 (Dipeptidyl peptidase-4)

Dipeptidyl peptidase-4 (DPP-4), also known as the T-cell antigen CD26, is a multi-functional protein which, besides its catalytic activity, also functions as a binding protein and a ligand for a variety of extracellular molecules. It is an integral membrane protein expressed on cells throughout the body, but is also shed from the membrane and circulates as a soluble protein in the plasma. A large number of bioactive molecules can be cleaved by DPP-4 in vitro, but only a few of these have been demonstrated to be physiological substrates. One of these is the incretin hormone, glucagon-like peptide-1 (GLP-1), which plays an important role in the maintenance of normal glucose homeostasis, and DPP-4 has been shown to be the key enzyme regulating its biological activity.

Ref:
Physiology and Pharmacology of DPP-4 in Glucose Homeostasis and the Treatment of Type 2 Diabetes Front. Endocrinol., 15 February 2019 Sec. Molecular and Structural Endocrinology Volume 10 - 2019 | https://doi.org/10.3389/fendo.2019.00080

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Added on Apr 28, 2022 by Barbara Van De Keer
Edited on Dec 2, 2023 by Barbara Van De Keer

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