concept

KATP (ATP-sensitive potassium channels)

ATP-sensitive potassium channels (KATP) are widely distributed and present in a number of tissues including muscle, pancreatic beta cells and the brain. Their activity is regulated by adenine nucleotides, characteristically being activated by falling ATP and rising ADP levels. Thus, they link cellular metabolism with membrane excitability.

Ref:
Tinker A, Aziz Q, Thomas A. The role of ATP-sensitive potassium channels in cellular function and protection in the cardiovascular system. Br J Pharmacol. 2014 Jan;171(1):12-23. doi: 10.1111/bph.12407. PMID: 24102106; PMCID: PMC3874693.

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Added on Jan 9, 2023 by Barbara Van De Keer

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