concept

NPY (neuropeptide Y)

Two orexigenic neuropeptides, neuropeptide Y (NPY) and agouti-related peptide (AGRP) are released by the same set of neurons within the arcuate nucleus of the hypothalamus (1). The expression of both neuropeptide genes are increased in negative caloric balance and loss of leptin signaling (2,–4). Both NPY and AGRP are considered to be important in producing hyperphagia, obesity, and infertility in cases of absent or diminished leptin signaling, such as complete leptin deficiency (5), lipodystrophy (6), and diet-induced obesity (7), although their relative contributions have not been directly compared.

Ref:
Luo N, Marcelin G, Liu SM, Schwartz G, Chua S Jr. Neuropeptide Y and agouti-related peptide mediate complementary functions of hyperphagia and reduced energy expenditure in leptin receptor deficiency. Endocrinology. 2011 Mar;152(3):883-9. doi: 10.1210/en.2010-1135. Epub 2011 Feb 1. PMID: 21285324; PMCID: PMC3040058.

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Added on Jan 9, 2023 by Barbara Van De Keer

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