enzyme

Tryptophan 2,3- dioxygenase (TDO2)

Entry into the kynurenine pathway begins with the conversion of tryptophan (TRP) into N-formylkynurenine (NFK) by one of three enzymes: indoleamine 2,3-dioxygenase 1, 2 (IDO1,2) and tryptophan 2,3-dioxygenase (TDO2) (Fig. 1). TDO2 usually functions as a tetramer while IDO functions as a monomer, and both functional enzymes contain a non-covalently bound iron-containing heme group per monomer. The iron-atom present in the heme group catalyzes the redox reaction of TRP with molecular oxygen (O2) to open the 5-member ring in TRP to form NFK (Nelp et al., 2018).

Ref:
Castro-Portuguez R, Sutphin GL. Kynurenine pathway, NAD+ synthesis, and mitochondrial function: Targeting tryptophan metabolism to promote longevity and healthspan. Exp Gerontol. 2020 Apr;132:110841. doi: 10.1016/j.exger.2020.110841. Epub 2020 Jan 16. PMID: 31954874; PMCID: PMC7053056.

20 confidence points
0 comments
Added on Mar 4, 2023 by Barbara Van De Keer
Edited on Mar 4, 2023 by Barbara Van De Keer

Join Ninatoka!!

NinatoKa's goal is to support you as a therapist in unravelling the illness pathway from symptoms to cause, and to help you detect potential interventions.

Go to Explore to start your discovery!

Go to Learn to scroll through newly added data.

Go to Contribute to contribute to the Ninatoka database.

You can rate content up or down and add comments if you agree or disagree.