process

Mitochondrial fission

Fission is promoted by excess nutrients, severe cellular stress and dysfunction (e.g. during cancer and obesity), and impaired oxidative phosphorylation. The resulting fragmented mitochondria are generally associated with metabolic dysfunction and disease, and are more susceptible to mitophagy (Weir et al., 2017)

Ref:
Castro-Portuguez R, Sutphin GL. Kynurenine pathway, NAD+ synthesis, and mitochondrial function: Targeting tryptophan metabolism to promote longevity and healthspan. Exp Gerontol. 2020 Apr;132:110841. doi: 10.1016/j.exger.2020.110841. Epub 2020 Jan 16. PMID: 31954874; PMCID: PMC7053056.

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Added on Mar 5, 2023 by Barbara Van De Keer

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