process

Mitochondrial fusion

Fusion is promoted by nutrient withdrawal, mild stress, and increased oxidative phosphorylation. Hyperfused mitochondria are protected from mitophagy and thought to preserve cellular integrity in response to metabolic stress and other insults.

Ref:
Castro-Portuguez R, Sutphin GL. Kynurenine pathway, NAD+ synthesis, and mitochondrial function: Targeting tryptophan metabolism to promote longevity and healthspan. Exp Gerontol. 2020 Apr;132:110841. doi: 10.1016/j.exger.2020.110841. Epub 2020 Jan 16. PMID: 31954874; PMCID: PMC7053056.

20 confidence points
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Added on Mar 5, 2023 by Barbara Van De Keer

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