enzyme

OPA1

The GTPases OPA1—localized to the inner mitochondrial membrane (IMM)—and mitofusin 1 and 2 (MFN1/2)—localized to the OMM—act in concert to bind and fuse the membranes of two mitochondrial segments (Byrne et al., 2019; Weir et al., 2017).

Ref:
Castro-Portuguez R, Sutphin GL. Kynurenine pathway, NAD+ synthesis, and mitochondrial function: Targeting tryptophan metabolism to promote longevity and healthspan. Exp Gerontol. 2020 Apr;132:110841. doi: 10.1016/j.exger.2020.110841. Epub 2020 Jan 16. PMID: 31954874; PMCID: PMC7053056.

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Added on Mar 5, 2023 by Barbara Van De Keer

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