concept

Naive lymphocyte

Typical T and B lymphocytes in the secondary lymphoid organs are long-lived cells that are selected from a large pool of short-lived precursor cells in the primary lymphoid organs. The bulk of mature T and B cells are immunologically naive and remain in interphase for prolonged periods. Contact with specific antigen causes these naive cells to proliferate rapidly and differentiate into a mixture of short-lived effector cells and long-lived memory cells. Memory cells have a rapid turnover, and the survival of these cells appears to require persistent contact with antigen.

Ref:
Sprent J. Lifespans of naive, memory and effector lymphocytes. Curr Opin Immunol. 1993 Jun;5(3):433-8. doi: 10.1016/0952-7915(93)90065-z. PMID: 8347304.

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Added on Mar 13, 2023 by Barbara Van De Keer

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