concept

Cyclic AMP (cAMP)

Cyclic adenosine monophosphate Cyclic AMP was first discovered by Dr. Earl W. Sutherland in 1958 for which he received a Nobel prize. Cyclic adenosine monophosphate is a small, hydrophilic molecule commonly known as cyclic AMP or cAMP, which is an important intracellular second messenger molecule regulated in many physiological processes. cAMP can trigger a cascade of events to influence cellular function through its interaction with protein effectors such as protein kinase A (PKA), exchange proteins activated by cAMP (EPACs), cyclic nucleotide-gated ion (CNG) channels, and hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Metabolism, gene regulation, regulation of neurotransmitter synthesis, growth factors, and immune function are some examples of the numerous biological processes that utilize cAMP.

Ref:
Patra C, Foster K, Corley JE, Dimri M, Brady MF. Biochemistry, cAMP. 2023 Jul 25. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 30571052.

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Added on Apr 7, 2022 by Barbara Van De Keer
Edited on Sep 17, 2023 by Barbara Van De Keer

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