enzyme

Matrix metalloproteinase (MMP)

Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes implicated in the invasion and metastasis of many kinds of cancer because of their ability to degrade components of extracellular matrix. Specific tissue inhibitors of matrix metalloproteinases (TIMPs) regulate their activity. MMPs and TIMPs were identified in many neoplasm, including cancers of head and neck, lung, breast and colon cancer. In most researches a strong relation between MMPs and TIMPs expression and a clinical course of disease was observed, although there were many discrepancies between the authors. The aim of this research was to evaluate the expression of MMP1, MMP2, MMP9 and TIMP1, TIMP2, TIMP3 in head and neck cancer and to investigate the prognostic impact of these factors in patients with these tumors. ------------------------------------------------------------ MMPs can be divided into five main groups based on protein structure: gelatinases (MMP-2 and MMP-9), collagenases (MMP-1, MMP-8, MMP-13, and MMP-18), stromelysins (MMP-3, MMP-10, and MMP-11), membrane-type MMPs (MMP-14, MMP-15, MMP-16, MMP-17, MMP-24, and MMP-25), and matrilysins (MMP-7 and MMP-26)

Ref:
Pietruszewska W, Bojanowska-Poźniak K, Kobos J. Matrix metalloproteinases MMP1, MMP2, MMP9 and their tissue inhibitors TIMP1, TIMP2, TIMP3 in head and neck cancer: an immunohistochemical study. Otolaryngol Pol. 2016 Jun 30;70(3):32-43. doi: 10.5604/00306657.1202546. PMID: 27386931. ------------------------------------------------------------ Gursoy-Ozdemir et al. Cortical spreading depression activates and upregulates MMP-9. J Clin Invest. 2004 PMID: 15146242

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Added on Apr 20, 2023 by Barbara Van De Keer
Edited on Jul 23, 2023 by Barbara Van De Keer

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