enzyme

Hormone sensitive lipase (HSL)

Hormone sensitive lipase (HSL) is an enzyme of relatively broad specificity, having the ability to hydrolyze tri-, di- and mono-acylglycerols as well as cholesterol esters and small water-soluble substrates. This broad specificity allows HSL to perform a variety of functions in several tissues. A key feature of HSL is its ability to be activated via phosphorylation by cyclic AMP-dependent protein kinase. In addition it is phosphorylated at a second site by several kinases, notably AMP-activated protein kinase.

Ref:
Yeaman SJ, Smith GM, Jepson CA, Wood SL, Emmison N. The multifunctional role of hormone-sensitive lipase in lipid metabolism. Adv Enzyme Regul. 1994;34:355-70. doi: 10.1016/0065-2571(94)90022-1. PMID: 7942281.

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Added on Apr 7, 2022 by Barbara Van De Keer
Edited on Nov 17, 2022 by Barbara Van De Keer

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