concept

Satellite cell

Since their discovery by Mauro (1961) satellite cells have been identified as the main source of new myonuclei in postnatal skeletal muscle tissue (Reznik, 1969; Moss and Leblond, 1970). The term “satellite cell” was coined owing to the anatomical location of these cells between the sarcolemma and basal lamina of their associated muscle fiber. In adult muscle, satellite cells typically reside in a quiescent state; however, upon stimulation they activate, proliferate and/or differentiate. Myoblasts, the progeny of satellite cells, can either fuse with each other forming new myofibers, fuse to an existing muscle fiber donating their nucleus to the fiber, or return to the quiescent state, replenishing the resident pool of satellite cells through self-renewal (Schmalbruch, 1976). The progression of the satellite cell through the myogenic program is thought to be orchestrated by the up- or down-regulation of the paired box transcription factor 7 (Pax7) and the myogenic regulatory factors (MRFs) (Seale et al., 2000).

Ref:
Front. Physiol., 21 October 2015 Sec. Exercise Physiology Volume 6 - 2015 | https://doi.org/10.3389/fphys.2015.00283

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Added on May 13, 2023 by Barbara Van De Keer

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