concept

Transient receptor potential (TRP)

The TRP ("transient receptor potential") family of ion channels now comprises more than 30 cation channels, most of which are permeable for Ca2+, and some also for Mg2+. On the basis of sequence homology, the TRP family can be divided in seven main subfamilies: the TRPC ('Canonical') family, the TRPV ('Vanilloid') family, the TRPM ('Melastatin') family, the TRPP ('Polycystin') family, the TRPML ('Mucolipin') family, the TRPA ('Ankyrin') family, and the TRPN ('NOMPC') family. The cloning and characterization of members of this cation channel family has exploded during recent years, leading to a plethora of data on the roles of TRPs in a variety of tissues and species, including mammals, insects, and yeast.

Ref:
Pedersen SF, Owsianik G, Nilius B. TRP channels: an overview. Cell Calcium. 2005 Sep-Oct;38(3-4):233-52. doi: 10.1016/j.ceca.2005.06.028. PMID: 16098585.

20 confidence points
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Added on Jun 1, 2023 by Barbara Van De Keer

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