process

Cori cycle

In the Cori cycle, glucose is metabolized to pyruvate and then to lactate in muscle, the lactate is released into the blood and carried to the liver, where it is reconverted to pyruvate and used for gluconeogenesis, and the resulting glucose is released and travels back to muscle. Lactate is a particularly good gluconeogenic substrate because the reoxidation of lactate to pyruvate in the lactate dehydrogenase reaction also provides the NADH equivalents needed for gluconeogenesis.

Ref:
Keith Tornheim, Glucose Metabolism and Hormonal Regulation☆, Editor(s): Ilpo Huhtaniemi, Luciano Martini, Encyclopedia of Endocrine Diseases (Second Edition), Academic Press, 2018, Pages 87-94, ISBN 9780128122006, https://doi.org/10.1016/B978-0-12-801238-3.03816-2. (https://www.sciencedirect.com/science/article/pii/B9780128012383038162)

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Added on Jun 15, 2022 by Barbara Van De Keer
Edited on Jan 9, 2023 by Barbara Van De Keer

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