concept

Protein 53 (P53)

The tumor suppressor p53 is a phosphoprotein barely detectable in the nucleus of normal cells. Upon cellular stress, particularly that induced by DNA damage, p53 can arrest cell cycle progression, thus allowing the DNA to be repaired; or it can lead to apoptosis. These functions are achieved, in part, by the transactivational properties of p53, which activate a series of genes involved in cell cycle regulation.

Ref:
Soussi T. The p53 tumor suppressor gene: from molecular biology to clinical investigation. Ann N Y Acad Sci. 2000 Jun;910:121-37; discussion 137-9. doi: 10.1111/j.1749-6632.2000.tb06705.x. PMID: 10911910.

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Added on Sep 3, 2023 by Barbara Van De Keer

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