enzyme

CYP2D6

Cytochrome P450 2D6 (CYP2D6) is a critical pharmacogene involved in the metabolism of ~20% of commonly used drugs across a broad spectrum of medical disciplines including psychiatry, pain management, oncology and cardiology. Nevertheless, CYP2D6 is highly polymorphic with single-nucleotide polymorphisms, small insertions/deletions and larger structural variants including multiplications, deletions, tandem arrangements, and hybridisations with non-functional CYP2D7 pseudogenes.

Ref:
Taylor C, Crosby I, Yip V, Maguire P, Pirmohamed M, Turner RM. A Review of the Important Role of CYP2D6 in Pharmacogenomics. Genes (Basel). 2020 Oct 30;11(11):1295. doi: 10.3390/genes11111295. PMID: 33143137; PMCID: PMC7692531.

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Added on Sep 8, 2023 by Barbara Van De Keer
Edited on Sep 8, 2023 by Barbara Van De Keer

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