concept

Follicle-stimulating hormone (FSH)

Follicle-Stimulating Hormone (FSH) is a gonadotropin synthesized and secreted from the anterior pituitary gland in response to slow-frequency pulsatile GnRH. FSH stimulates the growth and maturation of immature oocytes into mature (Graafian) secondary follicles before ovulation. FSH Receptors are G-protein coupled receptors and are found in the Granulosa cells that surround developing ovarian follicles. The granulosa cells initially produce the estrogen needed to maturate the developing dominant follicle. After 2 days of sustained elevation of estrogen levels, the LH surge causes luteinization of the granulosa cells into LH receptive cells. This transition enables granulosa cells to respond to LH levels and produce Progesterone.

Ref:
Holesh JE, Bass AN, Lord M. Physiology, Ovulation. 2023 May 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 28723025.

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Added on Feb 7, 2022 by Barbara Van De Keer
Edited on Sep 19, 2023 by Barbara Van De Keer

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