process

BH4 recycling

The recycling pathway occurs after the use of BH4 by aromatic amino acid hydroxylases (AAAHs) for the synthesis of monoamines and NO. Then BH4 is regenerated in two reactions: the hydroxy-4a derivative formed can be rapidly transformed into qBH2 via the removal of a water molecule and then regenerated to BH4 by dihydropteridine reductase (DHPR) [38]. In the absence or reduction of DHPR activity, qBH2 will rapidly be rearranged into BH2, which will be further reduced into BH4 through the salvage pathway. However, it has been shown in patients with DHPR mutations that regeneration of BH4 using DHFR is not as effective as DHPR [39].

Ref:
Fanet H, Capuron L, Castanon N, Calon F, Vancassel S. Tetrahydrobioterin (BH4) Pathway: From Metabolism to Neuropsychiatry. Curr Neuropharmacol. 2021;19(5):591-609. doi: 10.2174/1570159X18666200729103529. PMID: 32744952; PMCID: PMC8573752.

0 confidence points
0 comments
Added on Oct 22, 2023 by Barbara Van De Keer

Join Ninatoka!!

NinatoKa's goal is to support you as a therapist in unravelling the illness pathway from symptoms to cause, and to help you detect potential interventions.

Go to Explore to start your discovery!

Go to Learn to scroll through newly added data.

Go to Contribute to contribute to the Ninatoka database.

You can rate content up or down and add comments if you agree or disagree.