process

Aromatic L-amino acid decarboxylase (AAAD)

Serotonin is synthetized in two steps from tryptophan, an essential amino acid acquired from food. The first and limiting enzymatic step is hydroxylation by tryptophan-hydroxylase (TPH) to produce 5-hydroxytryptophan. The TPH1 isoform is found in EC cells, and the TPH2 isoform is located in central and enteric neurons. The next step is conversion to 5-hydroxytryptamine by an Serotonin is synthetized in two steps from tryptophan, an essential amino acid acquired from food. The first and limiting enzymatic step is hydroxylation by tryptophan-hydroxylase (TPH) to produce 5-hydroxytryptophan. The TPH1 isoform is found in EC cells, and the TPH2 isoform is located in central and enteric neurons. The next step is conversion to 5-hydroxytryptamine by an aromatic L-amino acid decarboxylase.

Ref:
Kanova, M.; Kohout, P. Serotonin—Its Synthesis and Roles in the Healthy and the Critically Ill. Int. J. Mol. Sci. 2021, 22, 4837. https://doi.org/10.3390/ijms22094837

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Added on Oct 22, 2023 by Barbara Van De Keer
Edited on Nov 16, 2023 by Barbara Van De Keer

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