enzyme

Phenylalanine decarboxylase

AAAD are pyridoxal 5′-phosphate (PLP)-dependent enzymes that convert aromatic amino acids into amines (Koyanagi et al., 2012). AAAD catalyze multiple reactions including the decarboxylation of L-DOPA into dopamine by DOPA decarboxylase; 5-HTP into serotonin by 5-HTP decarboxylase; tryptophan into tryptamine by tryptophan decarboxylase (TrpD); phenylalanine into phenylethylamine (PEA) by phenylalanine decarboxylase; tyrosine into tyramine by tyrosine decarboxylase (TyrD); histidine into histamine by histidine decarboxylase, among others (Wishart et al., 2018).

Ref:
Gonçalves S, Nunes-Costa D, Cardoso SM, Empadinhas N, Marugg JD. Enzyme Promiscuity in Serotonin Biosynthesis, From Bacteria to Plants and Humans. Front Microbiol. 2022 Apr 14;13:873555. doi: 10.3389/fmicb.2022.873555. PMID: 35495641; PMCID: PMC9048412.

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Added on Nov 16, 2023 by Barbara Van De Keer

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