concept

GIP (glucose-dependent insulinotropic polypeptide)

Incretin hormones are gut peptides that are secreted after nutrient intake and stimulate insulin secretion together with hyperglycaemia. GIP (glucose-dependent insulinotropic polypeptide) und GLP-1 (glucagon-like peptide-1) are the known incretin hormones from the upper (GIP, K cells) and lower (GLP-1, L cells) gut. Together, they are responsible for the incretin effect: a two- to three-fold higher insulin secretory response to oral as compared to intravenous glucose administration.

Ref:
Nauck MA, Meier JJ. Incretin hormones: Their role in health and disease. Diabetes Obes Metab. 2018 Feb;20 Suppl 1:5-21. doi: 10.1111/dom.13129. PMID: 29364588. Sec. Molecular and Structural Endocrinology Volume 10 - 2019 | https://doi.org/10.3389/fendo.2019.00080

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Added on Dec 2, 2023 by Barbara Van De Keer

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