concept

Parathyroid hormone (PTH)

In the blood, the sensitive process of calcium and phosphate homeostasis is maintained primarily by an appropriately functioning parathyroid gland. The parathyroid gland is comprised of 4 small glands located posteriorly to the thyroid in the middle aspect of the anterior neck. The parathyroid gland secretes parathyroid hormone (PTH), a polypeptide, in response to low calcium levels detected in the blood. PTH facilitates the synthesis of active vitamin D and calcitriol (1,25-dihydroxycholecalciferol) in the kidneys. In conjunction with calcitriol, PTH regulates calcium and phosphate. PTH effects are present in the bones, kidneys, and small intestines. As serum calcium levels drop, the secretion of PTH by the parathyroid gland increases. Increased calcium levels in the serum serve as a negative-feedback loop signaling the parathyroid glands to stop the release of PTH. The mechanism of PTH in the body is intricate, and the clinical ramifications of irregularities are significant.

Ref:
Khan M, Jose A, Sharma S. Physiology, Parathyroid Hormone. 2022 Oct 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 29763115.

0 confidence points
0 comments
Added on Dec 4, 2023 by Barbara Van De Keer
Edited on Dec 4, 2023 by Barbara Van De Keer

Join Ninatoka!!

NinatoKa's goal is to support you as a therapist in unravelling the illness pathway from symptoms to cause, and to help you detect potential interventions.

Go to Explore to start your discovery!

Go to Learn to scroll through newly added data.

Go to Contribute to contribute to the Ninatoka database.

You can rate content up or down and add comments if you agree or disagree.