enzyme

CYP1A1

The human cytochrome P450 (CYP) 1A1 gene encodes a monooxygenase that metabolizes multiple exogenous and endogenous substrates. CYP1A1 has become infamous for its oxidative metabolism of benzo[a]pyrene and related polycyclic aromatic hydrocarbons, converting these chemicals into very potent human carcinogens. CYP1A1 expression is mainly controlled by the aryl hydrocarbon receptor (AHR), a transcription factor whose activation is induced by binding of persistent organic pollutants, including polycyclic aromatic hydrocarbons and dioxins.

Ref:
Mescher M, Haarmann-Stemmann T. Modulation of CYP1A1 metabolism: From adverse health effects to chemoprevention and therapeutic options. Pharmacol Ther. 2018 Jul;187:71-87. doi: 10.1016/j.pharmthera.2018.02.012. Epub 2018 Feb 17. PMID: 29458109.

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Added on Jan 9, 2024 by Barbara Van De Keer
Edited on Jan 9, 2024 by Barbara Van De Keer

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