enzyme

GAD65

γ-Amino butyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain. It is synthesized through decarboxylation of glutamate by two isozymes of glutamic acid decarboxylase, (GAD)65 and GAD67. These two enzymes, which are named according to their respective molecular weights, are encoded by separate genes and underlie differential modes of regulation (Erlander et al. 1991; Kaufman et al. 1991).

Ref:
Müller I, Çalışkan G, Stork O. The GAD65 knock out mouse - a model for GABAergic processes in fear- and stress-induced psychopathology. Genes Brain Behav. 2015 Jan;14(1):37-45. doi: 10.1111/gbb.12188. PMID: 25470336.

20 confidence points
0 comments
Added on May 26, 2024 by Barbara Van De Keer

Join Ninatoka!!

NinatoKa's goal is to support you as a therapist in unravelling the illness pathway from symptoms to cause, and to help you detect potential interventions.

Go to Explore to start your discovery!

Go to Learn to scroll through newly added data.

Go to Contribute to contribute to the Ninatoka database.

You can rate content up or down and add comments if you agree or disagree.