concept

SAM-e (S-adenosylmethionine, SAMe)

S-Adenosyl-Lmethionine (SAM) is an important molecule in normal cell function and survival. SAM is utilized by three key metabolic pathways: transmethylation; transsulfuration; and polyamine synthesis. In transmethylation reactions, the methyl group of SAM is donated to a large variety of acceptor substrates including DNA, phospholipids and proteins. Thus, interference of these reactions can affect a wide spectrum of processes ranging from gene expression to membrane fluidity. In transsulfuration, the sulfur atom of the SAM is converted via a series of enzymatic steps to cysteine, a precursor of taurine and glutathione, a major cellular anti-oxidant. Polyamines are required for normal cell growth.

Ref:
Lu SC. S-Adenosylmethionine. Int J Biochem Cell Biol. 2000 Apr;32(4):391-5. doi: 10.1016/s1357-2725(99)00139-9. PMID: 10762064.

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Added on Feb 1, 2022 by Barbara Van De Keer
Edited on Dec 2, 2023 by Barbara Van De Keer

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