concept

GLUT3

GLUT3 is always saturated with glucose to prevent surges and drops of glucose. GLUTs 1, 3, and 4 are transporters that have high affinity for glucose ranging in Km of 2–5 mM glucose. Consequently, the functions of these transporters align with the physiological concentration of glucose of about 5 mM. GLUT3 has a low Km for glucose of 1.6 mM. It transports glucose into brain cells at a rate that is independent of the plasma level of glucose when it exceeds the physiological range of 4–10 mM.

Ref:
Gerald Litwack, Chapter 8 - Glycolysis and Gluconeogenesis, Editor(s): Gerald Litwack, Human Biochemistry, Academic Press, 2018, Pages 183-198, ISBN 9780123838643, https://doi.org/10.1016/B978-0-12-383864-3.00008-9. (https://www.sciencedirect.com/science/article/pii/B9780123838643000089)

20 confidence points
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Added on Jun 6, 2022 by Barbara Van De Keer
Edited on Jan 7, 2023 by Barbara Van De Keer

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